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Article

Abnormal phenotype of cultured fibroblasts in human skin with chronic radiotherapy damage.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Jun 1998

Delanian S, Martin M, Bravard A, Luccioni C, Lefaix J L

Abstract excerpt

PURPOSE: The pathophysiological aspects of radiation-induced fibrosis (RIF) have not been well characterized. We therefore cultured human fibroblasts from samples of skin with RIF to investigate the long-term effects of therapeutic irradiation. MATERIALS AND METHODS: Biopsies of normal and RIF skin were obtained from patients previously irradiated for cancer, without recurrence. Cells were extracted from dermis...

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PMID: 9681888
DOI: 10.1016/s0167-8140(97)00195-3

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