Article
Mfsd2a (Major Facilitator Superfamily Domain Containing 2a) Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Inhibiting Vesicular Transcytosis.
Journal of the American Heart Association - 19 Jul 2017
Yang Yuan-Rui, Xiong Xiao-Yi, Liu Juan, Wu Li-Rong, Zhong Qi, Zhou Kai, Meng Zhao-You, Liu Liang, Wang Fa-Xiang, Gong Qiu-Wen, Liao Mao-Fan, Duan Chun-Mei, Li Jie, Yang Mei-Hua, Zhang Qin, Gong Chang-Xiong, Yang Qing-Wu
Abstract excerpt
BACKGROUND: Blood-brain barrier (BBB) disruption aggravates brain injury induced by intracerebral hemorrhage (ICH); however, the mechanisms of BBB damage caused by ICH remain elusive. Mfsd2a (major facilitator superfamily domain containing 2a) has been known to play an essential role in BBB formation and function. In this study, we investigated the role and underlying mechanisms of Mfsd2a in BBB permeability...
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