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Article

Zika virus degrades the ω-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis.

Science advances - 1 Oct 2019

Zhou Jia, Chi Xiaojing, Cheng Min, Huang Xingyao, Liu Xiuying, Fan Jingjing, Xu Hua, Lin Tianli, Shi Lei, Qin Chengfeng, Yang Wei

Abstract excerpt

Zika virus (ZIKV) infection during pregnancy increases the risk of postnatal microcephaly. Neurovascular function provides a homeostatic environment for proper brain development. The major facilitator superfamily domain-containing protein 2 (Mfsd2a) is selectively expressed in human brain microvascular endothelial cells (hBMECs) and is the major transporter mediating the brain uptake of docosahexaenoic acid...

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Identifiers

PMID: 31681849
DOI: 10.1126/sciadv.aax7142
PMCID: PMC6810275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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