Article
Longitudinal analysis of motor symptoms and histopathology in woozy mice, a model of cerebellar ataxia.
Neuroreport - 6 Sept 2017
Hayashi Takemitsu, Onozato Tomoya, Wanajo Isao, Hayashi Morimichi, Takeda Hiroo, Fujimori Yoshikazu
Abstract excerpt
Woozy (wz) mice develop ataxia and carry a mutation in the Sil1 gene. Homozygous wz mice have been characterized histopathologically, but no details of their motor function have been reported. In the present study, to comprehensively understand the relationship between symptomatic progression and pathological feature, we evaluated motor function and neurodegeneration with age from presymptomatic to terminal...
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