Article
Loss of the tumour suppressor gene AIP mediates the browning of human brown fat tumours.
The Journal of pathology - 1 Oct 2017
Magnusson Linda, Hansen Nils, Saba Karim H, Nilsson Jenny, Fioretos Thoas, Rissler Pehr, Nord Karolin H
Abstract excerpt
Human brown fat tumours (hibernomas) show concomitant loss of the tumour suppressor genes MEN1 and AIP. We hypothesized that the brown fat phenotype is attributable to these mutations. Accordingly, in this study, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumours, loss of MEN1 was found both...
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