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Article

Concomitant deletions of tumor suppressor genes <i>MEN1</i> and <i>AIP</i> are essential for the pathogenesis of the brown fat tumor hibernoma

15 Nov 2010

Abstract excerpt

Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor suppressor genes that are located 3 Mb apart and that underlie the hereditary syndromes pituitary adenoma...

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PMID: 21078971
DOI: 10.1073/pnas.1013512107

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Concomitant deletions of tumor suppressor genes <i>MEN1</i> and <i>AIP</i> are essential for the pathogenesis of the brown fat tumor hibernomaPMID 21078971Read ↗

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