Article
Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha.
The Journal of biological chemistry - 14 Jun 2002
Carmona M Carmen, Iglesias Roser, Obregón María-Jesús, Darlington Gretchen J, Villarroya Francesc, Giralt Marta
Abstract excerpt
Brown fat differentiation in mice is fully achieved in fetuses at term and entails the acquisition of not only adipogenic but also thermogenic and oxidative mitochondrial capacities. The present study of the mice homozygous for a deletion in the gene for CCAAT/enhancer-binding protein alpha (C/EBPalpha-null mice) demonstrates that C/EBPalpha is essential for all of these processes. Developing brown fat from...
Topics
- Adipose Tissue, Brown
- Animals
- Blotting, Northern
- Blotting, Western
- CCAAT-Enhancer-Binding Protein-beta
- CCAAT-Enhancer-Binding Protein-delta
- CCAAT-Enhancer-Binding Proteins
- Carrier Proteins
- Cell Differentiation