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Article

Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells

11 Jul 2017

Abstract excerpt

The R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs) comprises PTPRZ and PTPRG. A recent study on primary human glioblastomas suggested a close association between PTPRZ1 (human PTPRZ) expression and cancer stemness. However, the functional roles of PTPRZ activity in glioma stem cells have remained unclear. In the present study, we found that sphere-forming cells from the rat C6 and human U251...

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PMID: 28717188
DOI: 10.1038/s41598-017-05931-8

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