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Suppression of Glioblastoma Stem Cell Potency and Tumor Growth via LRRK2 Inhibition

8 Apr 2024

Abstract excerpt

studies. Orthotopic patient-derived xenograft mouse models demonstrated that LRRK2 inhibition with DNK72 effectively reduced tumor growth and increased survival time. We propose that LRRK2 plays a significant role in regulating the stemness of GSCs and that suppression of LRRK2 kinase activity leads to reduced GBM malignancy and proliferation. In the near future, targeting LRRK2 in patients with high...

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PMID: 38584542
DOI: 10.15283/ijsc24032

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