Article
PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature.
Molecular cancer therapeutics - 1 Oct 2017
Efimenko Evgeni, Davé Utpal P, Lebedeva Irina V, Shen Yao, Sanchez-Quintero Maria J, Diolaiti Daniel, Kung Andrew, Lannutti Brian J, Chen Jianchung, Realubit Ronald, Niatsetskaya Zoya, Ten Vadim, Karan Charles, Chen Xi, Califano Andrea, Diacovo Thomas G
Abstract excerpt
PI3K/AKT and NOTCH1 signaling pathways are frequently dysregulated in T-cell acute lymphoblastic leukemias (T-ALL). Although we have shown that the combined activities of the class I PI3K isoforms p110γ and p110δ play a major role in the development and progression of PTEN-null T-ALL, it has yet to be determined whether their contribution to leukemogenic programing is unique from that associated with NOTCH1...
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