Article
miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an "ALT-like" phenotype in diffuse malignant peritoneal mesothelioma cells.
Journal of hematology & oncology - 17 Jul 2017
Cimino-Reale Graziella, Gandellini Paolo, Santambrogio Francesca, Recagni Marta, Zaffaroni Nadia, Folini Marco
Abstract excerpt
BACKGROUND: Understanding the molecular/cellular underpinnings of diffuse malignant peritoneal mesothelioma (DMPM), a fatal malignancy with limited therapeutic options, is of utmost importance for the fruitful management of the disease. In this context, we previously found that telomerase activity (TA), which accounts for the limitless proliferative potential of cancer cells, is prognostic for disease relapse and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.