Article
Total deletion of in vivo telomere elongation capacity: an ambitious but possibly ultimate cure for all age-related human cancers.
Annals of the New York Academy of Sciences - 1 Jun 2004
de Grey Aubrey D N J, Campbell F Charles, Dokal Inderjeet, Fairbairn Leslie J, Graham Gerry J, Jahoda Colin A B, Porterg Andrew C G
Abstract excerpt
Despite enormous effort, progress in reducing mortality from cancer remains modest. Can a true cancer "cure" ever be developed, given the vast versatility that tumors derive from their genomic instability? Here we consider the efficacy, feasibility, and safety of a therapy that, unlike any available or in development, could never be escaped by spontaneous changes of gene expression: the total elimination from the...
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