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Immune dysfunctionality of replicative senescent mesenchymal stromal cells is corrected by IFNγ priming

17 Apr 2017

Abstract excerpt

Industrial-scale expansion of mesenchymal stromal cells (MSCs) is often used in clinical trials, and the effect of replicative senescence on MSC functionality is of mechanistic interest. Senescent MSCs exhibit cell-cycle arrest, cellular hypertrophy, and express the senescent marker β-galactosidase. Although both fit and senescent MSCs display intact lung-homing properties in vivo, senescent MSCs acquire a...

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PMID: 28713871
DOI: 10.1182/bloodadvances.2017006205

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