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CD26 is a senescence marker associated with reduced immunopotency of human adipose tissue-derived multipotent mesenchymal stromal cells

26 Jul 2022

Abstract excerpt

Abstract Introduction Human mesenchymal stromal cells (MSCs) have immunomodulatory, anti-inflammatory, and tolerogenic effects. Long-term in vitro expansion of MSCs to generate clinical grade products results in the accumulation of senescent-functionally impaired MSCs. Markers to assess the ‘senescent load’ of MSC products are needed. Methods Early and late passage human adipose tissue (AT) MSCs from pediatric...

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PMID: 35883188
DOI: 10.1186/s13287-022-03026-4

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