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Article

Boundary Cap Neural Crest Stem Cells Promote Survival of Mutant SOD1 Motor Neurons.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Jul 2017

Aggarwal Tanya, Hoeber Jan, Ivert Patrik, Vasylovska Svitlana, Kozlova Elena N

Abstract excerpt

ALS is a devastating disease resulting in degeneration of motor neurons (MNs) in the brain and spinal cord. The survival of MNs strongly depends on surrounding glial cells and neurotrophic support from muscles. We previously demonstrated that boundary cap neural crest stem cells (bNCSCs) can give rise to neurons and glial cells in vitro and in vivo and have multiple beneficial effects on co-cultured and...

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Identifiers

PMID: 28070746
DOI: 10.1007/s13311-016-0505-8
PMCID: PMC5509618

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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