Mutational insertion of a ROSA26-EGFP transgene leads to defects in spermiogenesis and male infertility in mice.

Abstract excerpt

Pronuclear injection has been a successful strategy for generating genetically engineered mouse models to better understand the functionality of genes. A characteristic of pronuclear injection is that random integration of the transgene into the genome can disturb a functional gene and result in a phenotype unrelated to the transgene itself. In this study, we have characterized a mouse model containing an...

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