Article
Removal of a consensus proline is not sufficient to allow tetratricopeptide repeat oligomerization.
Protein science : a publication of the Protein Society - 1 Oct 2017
Bakkum Amber L, Hill R Blake
Abstract excerpt
Tetratricopeptide repeat (TPR) domains are ubiquitous protein interaction domains that adopt a modular antiparallel array of α-helices. The TPR fold typically adopts a monomeric state, and consensus TPRs sequences successfully fold into the expected monomeric topology. The versatility of the TPR fold also supports different quaternary structures, which may function as regulatory switches. One example is yeast...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.