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Article

Self-association of TPR domains: Lessons learned from a designed, consensus-based TPR oligomer.

Proteins - 1 Jul 2010

Krachler Anne Marie, Sharma Amit, Kleanthous Colin

Abstract excerpt

The tetratricopeptide repeat (TPR) motif is a protein-protein interaction module that acts as an organizing centre for complexes regulating a multitude of biological processes. Despite accumulating evidence for the formation of TPR oligomers as an additional level of regulation there is a lack of structural and solution data explaining TPR self-association. In the present work we characterize the trimeric...

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Source

Identifiers

PMID: 20455268
DOI: 10.1002/prot.22726

Genes

TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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