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Article

The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle.

Journal of molecular biology - 28 Nov 2003

Suzuki Motoshi, Jeong Seon Yong, Karbowski Mariusz, Youle Richard J, Tjandra Nico

Abstract excerpt

Fis1 in yeast localizes to the outer mitochondrial membrane and facilitates mitochondrial fission by forming protein complexes with Dnm1 and Mdv1. Fis1 orthologs exist in higher eukaryotes, suggesting that they are functionally conserved. In the present study, we cloned the human Fis1 ortholog that was predicted in a database, and determined the protein structure using NMR spectroscopy. Following a flexible...

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Identifiers

PMID: 14623186
DOI: 10.1016/j.jmb.2003.09.064

Genes

TPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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