Article
Structure-based analysis of A19D, a variant of transthyretin involved in familial amyloid cardiomyopathy.
PloS one - 1 Jan 2013
Ferreira Priscila, Sant'Anna Ricardo, Sant'Anna Oliveira, Varejão Nathalia, Lima Cinthia, Novis Shenia, Barbosa Renata V, Caldeira Concy M, Rumjanek Franklin D, Ventura Salvador, Cruz Marcia W, Foguel Debora
Abstract excerpt
Transthyretin (TTR) is a tetrameric beta-sheet-rich protein. Its deposits have been implicated in four different amyloid diseases. Although aggregation of the wild-type sequence is responsible for the senile form of the disease, more than one hundred variants have been described thus far, most of which confer a more amyloidogenic character to TTR, mainly because they compromise the stability of the protein in...
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