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Article

Cux1 promotes cell proliferation and polycystic kidney disease progression in an ADPKD mouse model.

American journal of physiology. Renal physiology - 1 Oct 2017

Porath Binu, Livingston Safia, Andres Erica L, Petrie Alexandra M, Wright Joshua C, Woo Anna E, Carlton Carol G, Baybutt Richard, Vanden Heuvel Gregory B

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic hereditary disorders in humans characterized by fluid-filled cysts, primarily in the kidneys. Cux1, a cell cycle regulatory gene highly expressed during kidney development, is elevated in the cyst-lining cells of Pkd1 mutant mice, and in human ADPKD cells. However, forced expression of Cux1 is insufficient to induce cystic...

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Identifiers

PMID: 28701314
DOI: 10.1152/ajprenal.00380.2016
PMCID: PMC5668583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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