Article
Clinical Phenotypes and Outcomes in Monogenic Versus Non-monogenic Very Early Onset Inflammatory Bowel Disease.
Journal of Crohn's & colitis - 8 Sept 2022
Collen Lauren V, Kim David Y, Field Michael, Okoroafor Ibeawuchi, Saccocia Gwen, Whitcomb Sydney Driscoll, Green Julia, Dong Michelle Dao, Barends Jared, Carey Bridget, Weatherly Madison E, Rockowitz Shira, Sliz Piotr, Liu Enju, Eran Alal, Grushkin-Lerner Leslie, Bousvaros Athos, Muise Aleixo M, Klein Christoph, Mitsialis Vanessa, Ouahed Jodie, Snapper Scott B
Abstract excerpt
BACKGROUND AND AIMS: Over 80 monogenic causes of very early onset inflammatory bowel disease [VEOIBD] have been identified. Prior reports of the natural history of VEOIBD have not considered monogenic disease status. The objective of this study is to describe clinical phenotypes and outcomes in a large single-centre cohort of patients with VEOIBD and universal access to whole exome sequencing [WES]. METHODS:...
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