Article
Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies.
Inflammatory bowel diseases - 12 May 2020
Ouahed Jodie, Spencer Elizabeth, Kotlarz Daniel, Shouval Dror S, Kowalik Matthew, Peng Kaiyue, Field Michael, Grushkin-Lerner Leslie, Pai Sung-Yun, Bousvaros Athos, Cho Judy, Argmann Carmen, Schadt Eric, Mcgovern Dermot P B, Mokry Michal, Nieuwenhuis Edward, Clevers Hans, Powrie Fiona, Uhlig Holm, Klein Christoph, Muise Aleixo, Dubinsky Marla, Snapper Scott B
Abstract excerpt
Very early onset inflammatory bowel disease (VEO-IBD) is defined as IBD presenting before 6 years of age. When compared with IBD diagnosed in older children, VEO-IBD has some distinct characteristics such as a higher likelihood of an underlying monogenic etiology or primary immune deficiency. In addition, patients with VEO-IBD have a higher incidence of inflammatory bowel disease unclassified (IBD-U) as compared...
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