Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia.

doi:10.1002/ijc.30883

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Article

Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia.

International journal of cancer - 1 Nov 2017

Gu Fangyi, Zhang Han, Hyland Paula L, Berndt Sonja, Gapstur Susan M, Wheeler William, Ellipse Consortium The, Amos Christopher I, Bezieau Stephane, Bickeböller Heike, Brenner Hermann, Brennan Paul, Chang-Claude Jenny, Conti David V, Doherty Jennifer Anne, Gruber Stephen B, Harrison Tabitha A, Hayes Richard B, Hoffmeister Michael, Houlston Richard S, Hung Rayjean J, Jenkins Mark A, Kraft Peter, Lawrenson Kate, McKay James, Markt Sarah, Mucci Lorelei, Phelan Catherine M, Qu Conghui, Risch Angela, Rossing Mary Anne, Wichmann H-Erich, Shi Jianxin, Schernhammer Eva, Yu Kai, Landi Maria Teresa, Caporaso Neil E

Abstract excerpt

Circadian disruption has been linked to carcinogenesis in animal models, but the evidence in humans is inconclusive. Genetic variation in circadian rhythm genes provides a tool to investigate such associations. We examined associations of genetic variation in nine core circadian rhythm genes and six melatonin pathway genes with risk of colorectal, lung, ovarian and prostate cancers using data from the Genetic...

Topics

Arylalkylamine N-Acetyltransferase
Basic Helix-Loop-Helix Transcription Factors
Carcinogenesis
Circadian Rhythm
Colorectal Neoplasms
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Association Studies

Genetic Predisposition to Disease

Humans

Lung Neoplasms

Male

Nerve Tissue Proteins

Ovarian Neoplasms

Polymorphism, Single Nucleotide

Prostatic Neoplasms

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 28699174
DOI: 10.1002/ijc.30883
PMCID: PMC5907928

Genes

AANAT
NPAS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-28699174-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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