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Article

Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty.

Scientific reports - 11 Jul 2017

Elo Teresa, Lindfors Päivi H, Lan Qiang, Voutilainen Maria, Trela Ewelina, Ohlsson Claes, Huh Sung-Ho, Ornitz David M, Poutanen Matti, Howard Beatrice A, Mikkola Marja L

Abstract excerpt

Mammary gland development begins with the appearance of epithelial placodes that invaginate, sprout, and branch to form small arborized trees by birth. The second phase of ductal growth and branching is driven by the highly invasive structures called terminal end buds (TEBs) that form at ductal tips at the onset of puberty. Ectodysplasin (Eda), a tumor necrosis factor-like ligand, is essential for the development...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28698625
DOI: 10.1038/s41598-017-04637-1
PMCID: PMC5505952

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