Article
Prostate Cancer Screening in a New Era of Genetics.
Clinical genitourinary cancer - 1 Dec 2017
Cheng Heather H, Pritchard Colin C, Montgomery Bruce, Lin Daniel W, Nelson Peter S
Abstract excerpt
Men who inherit pathogenic germline mutations in BRCA2 and BRCA1 are at increased risk of developing aggressive prostate cancer, and those with germline mutations in other DNA repair genes such as ATM, CHEK2, and MSH2/MSH6 may also have increased risks. Although clinically important, there is lack of specific guidance regarding management strategies for men at increased risk owing to germline mutation status or...
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