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Article

Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver

2020-02-19

Abstract excerpt

RNA knockdown in vivo carries significant potential for disease modelings and therapies. Despite the emerging approaches of CRISPR/Cas9-mediated permanent knock out of targeted genes, strategies targeting RNA for disruption are advantageous in the treatment of acquired metabolic disorders when permanent modification of the genome DNA is not appropriate, and RNA virus infection diseases when pathogenic DNA is not...

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Identifiers and source

Literature Corpus work
4173f245-fa6b-51fe-919d-135377bbbf18
DOI
10.1101/2020.02.17.945014
Open publication

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Modulation of metabolic functions through Cas13d-mediated gene knockdown in liverDOI 10.1101/2020.02.17.945014
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