[Rheumatoid arthritis pathogenesis. From susceptibility to autoimmunity, and arthritis].

Abstract excerpt

Rheumatoid arthritis is a systemic autoimmune disease with a multifactorial etiology, resulting from the interaction between genetic susceptibility and environmental factors. These interactions lead to the loss of immune tolerance and the development of autoimmunity directed against citrullinated proteins. The transition to arthritis is accompanied by the maturation of the humoral immune response and the...

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