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Article

Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia

10 Jul 2017

Abstract excerpt

BACKGROUND: Current conventional chemotherapy for acute myeloid leukemia (AML) can achieve remission in over 70% of patients, but a majority of them will relapse within 5 years despite continued treatment. The relapse is postulated to be due to leukemia stem cells (LSCs), which are different from normal hematopoietic stem cells (HSCs). LIN28B is microRNA regulator and stem cell reprogramming factor....

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PMID: 28693523
DOI: 10.1186/s13045-017-0507-y

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