Article

KIAA1429 regulates the expression of RAB27B in a m6A YTHDF1 axis-dependent manner and promotes the progression of chronic myeloid leukemia, serving as a potential therapeutic target

2022-09-22

Abstract excerpt

<h4>Background: </h4> Chronic myeloid leukemia (CML) is one of the most common adult leukemias. The considerable negative changes in its acute phase and the adverse drug effects could lead to poor prognosis. N6-methyladenine (m6A) modification plays an important regulatory role in physiological and pathological processes. KIAA1429 is an important m6A regulator, but the biological role of KIAA1429 in CML is still u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d64e3a2-e54a-50a0-b452-b5639d510373
DOI: 10.21203/rs.3.rs-2072636/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

KIAA1429 regulates the expression of RAB27B in a m6A YTHDF1 axis-dependent manner and promotes the progression of chronic myeloid leukemia, serving as a potential therapeutic targetDOI 10.21203/rs.3.rs-2072636/v1Read

Construction of an acute myeloid leukemia prognostic model based on m6A-related efferocytosis-related genesSemantic proximity Read

Main N6-Methyladenosine Readers: YTH Family Proteins in CancersSemantic proximity Read

LIN28A-Dependent Kinome and Phosphoproteome Reprogramming Promotes Imatinib ResistanceSemantic proximity Read

M6A RNA methylation in biliary tract cancer: the function roles and potential therapeutic implicationsSemantic proximity Read

The RNA N⁶-Methyladenosine Methylome Coordinates Long Non-Coding RNAs to Mediate Cancer Drug Resistance by Activating PI3K SignalingSemantic proximity Read

RNA demethylase ALKBH5 promotes tumorigenesis of t (8;21) acute myeloid leukemia via ITPA m6A modificationSemantic proximity Read

KDM4C contributes to cytarabine resistance in acute myeloid leukemia via regulating the miR-328-3p/CCND2 axis through MALAT1Semantic proximity Read

Tumor Suppressor DYRK1A Effects on Proliferation and Chemoresistance of AML Cells by Downregulating c-MycSemantic proximity Read

N6-methyladenosine modification regulates imatinib resistance of gastrointestinal stromal tumor by enhancing the expression of multidrug transporter MRP1Semantic proximity Read

Clinical Significance And Potential Mechanisms of The RNA Methyltransferase KIAA1429 In OsteosarcomaSemantic proximity Read

Reduced YTHDF2 inhibits PD-L1 expression by stabilizing m6A-containing SPOP mRNA in colorectal cancerSemantic proximity Read

The roles of microRNAs in the pathogenesis and drug resistance of chronic myelogenous leukemia (Review)Semantic proximity Read