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Article

Clock1a affects mesoderm development and primitive hematopoiesis by regulating Nodal-Smad3 signaling in the zebrafish embryo.

The Journal of biological chemistry - 25 Aug 2017

Bian Sha-Sha, Zheng Xu-Lei, Sun Hua-Qin, Chen Jian-Hui, Lu Yi-Lu, Liu Yun-Qiang, Tao Da-Chang, Ma Yong-Xin

Abstract excerpt

Circadian clock and Smad2/3/4-mediated Nodal signaling regulate multiple physiological and pathological processes. However, it remains unknown whether Clock directly cross-talks with Nodal signaling and how this would regulate embryonic development. Here we show that Clock1a coordinated mesoderm development and primitive hematopoiesis in zebrafish embryos by directly up-regulating Nodal-Smad3 signaling. We found...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28687631
DOI: 10.1074/jbc.M117.794289
PMCID: PMC5572899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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