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Article

Functional role of residues involved in substrate binding of human 4-hydroxyphenylpyruvate dioxygenase.

The Biochemical journal - 25 Jun 2021

Huang Chih-Wei, Hwang Chi-Ching, Chang Yung-Lung, Liu Jen-Tzu, Wu Sheng-Peng, Huang Kai-Ling, Huang Wei-Min, Lee Hwei-Jen

Abstract excerpt

4-Hydroxylphenylpyruvate dioxygenase (HPPD) catalyzes the conversion of 4-hydroxylphenylpyruvate (HPP) to homogentisate, the important step for tyrosine catabolism. Comparison of the structure of human HPPD with the substrate-bound structure of A. thaliana HPPD revealed notably different orientations of the C-terminal helix. This helix performed as a closed conformation in human enzyme. Simulation revealed a...

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PMID: 34047349
DOI: 10.1042/BCJ20210005

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