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Assessment of circulating copy number variant detection for cancer screening

7 Jul 2017

Abstract excerpt

Current high-sensitivity cancer screening methods, largely utilizing correlative biomarkers, suffer from false positive rates that lead to unnecessary medical procedures and debatable public health benefit overall. Detection of circulating tumor DNA (ctDNA), a causal biomarker, has the potential to revolutionize cancer screening. Thus far, the majority of ctDNA studies have focused on detection of tumor-specific...

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PMID: 28686671
DOI: 10.1371/journal.pone.0180647

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