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Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo

15 Jun 2012

Abstract excerpt

BACKGROUND: Many miR genes are located within or around CpG islands. It is unclear whether methylation of these CpG islands represses miR transcription regularly. The aims of this study are to characterize gastric carcinoma (GC)-related methylation of miR CpG islands and its relationship with miRNA expression. METHODS: Methylation status of 9 representative miR CpG islands in a panel of cell lines and human...

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Share to Epigenetics and DNA Methylation
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PMID: 22703336
DOI: 10.1186/1471-2407-12-249

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