LINE-1 Hypomethylation Is Associated with Increased CpG Island Methylation in <i>Helicobacter pylori</i>–Related Enlarged-Fold Gastritis

Abstract excerpt

BACKGROUND: The molecular mechanism by which Helicobacter pylori infection leads to gastric cancer is not fully understood. Similarly, patients with enlarged-fold (EF+) gastritis, one cause of which is H. pylori infection, have an increased risk for gastric cancer, although again molecular mechanism is unclear. In the present study, we analyzed the methylation status of long interspersed nucleotide elements...

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