Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunodeficiency in Pancreatic Adenocarcinoma with Diabetes Revealed by Comparative Genomics.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2017

Yan Yuanqing, Gao Ruli, Trinh Thao L P, Grant Maria B

Abstract excerpt

Purpose: Pancreatic adenocarcinomas (PAAD) often are not diagnosed until their late stages, leaving no effective treatments. Currently, immunotherapy provides a promising treatment option against this malignancy. However, a set of immunotherapy agents benefit patients with many types of cancer, but not PAAD. Sharing the origin in the same organ, diabetes and PAAD tend to occur concurrently. We aimed to identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Genetic
Share to Diabetes Complications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus

Share to Disease Susceptibility

Share to DNA Copy Number Variations

Share to Immunity

Share to Neoplasm Staging

Share to Pancreatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 28684632
DOI: 10.1158/1078-0432.CCR-17-0250
PMCID: PMC6022738

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunodeficiency in Pancreatic Adenocarcinoma with Diabetes Revealed by Comparative Genomics.PMID 28684632Read ↗

Immune-related somatic mutation genes are enriched in PDACs with diabetesSemantic proximity Read ↗

Identification of Genetic Determinants of Pancreatic Cancer Immune Phenotypes by Integrative Genome-scale AnalysisSemantic proximity Read ↗

Multi-omics analysis based on integrated genomics, epigenomics and transcriptomics in pancreatic cancer.Semantic proximity Read ↗

Assessment of genetic alterations found in type 2 diabetes mellitus patients with pancreatic adenocarcinomaSemantic proximity Read ↗

Comparative bioinformatical analysis of pancreatic head cancer and pancreatic body/tail cancer.Semantic proximity Read ↗

Driver mutation subtypes involve with differentiated immunophenotypes influencing pancreatic cancer outcomes.Semantic proximity Read ↗

CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinomaSemantic proximity Read ↗

A DNA-Methylation-Driven Genes Based Prognostic Signature Reveals Immune Microenvironment in Pancreatic CancerSemantic proximity Read ↗

Integrative analyzes of biomarkers and pathways for exploration the mechanisms and targets associated with pyroptosis in type 2 diabetesSemantic proximity Read ↗

Unraveling the role of Major Vault Protein as a novel immune-related biomarker that promotes the proliferation and migration in pancreatic adenocarcinomaSemantic proximity Read ↗

Pancancer analysis uncovers an immunological role and prognostic value of the m6A reader IGF2BP2 in pancreatic cancerSemantic proximity Read ↗

Immunological mutational signature in adenosquamous cancer of pancreas: an exploratory study of potentially therapeutic targets.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.