Article
Characterization of H-box region mutants of WalK inert to the action of waldiomycin in Bacillus subtilis.
The Journal of general and applied microbiology - 5 Sept 2017
Kato Akinori, Ueda Shuhei, Oshima Taku, Inukai Yoichi, Okajima Toshihide, Igarashi Masayuki, Eguchi Yoko, Utsumi Ryutaro
Abstract excerpt
The WalK/WalR two-component system is essential for cell wall metabolism and thus for cell growth in Bacillus subtilis. Waldiomycin was previously isolated as an antibiotic that targeted WalK, the cognate histidine kinase (HK) of the response regulator, WalR, in B. subtilis. To gain further insights into the action of waldiomycin on WalK and narrow down its site of action, mutations were introduced in the H-box...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.