Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vancomycin susceptibility in methicillin-resistant Staphylococcus aureus is mediated by YycHI activation of the WalRK essential two-component regulatory system.

Scientific reports - 7 Sept 2016

Cameron David R, Jiang Jhih-Hang, Kostoulias Xenia, Foxwell Daniel J, Peleg Anton Y

Abstract excerpt

The treatment of infections caused by methicillin-resistant Staphylococcus aureus is complicated by the emergence of strains with intermediate-level resistance to vancomycin (termed VISA). We have characterised a molecular pathway involved in the in vivo evolution of VISA mediated by the regulatory proteins YycH and YycI. In contrast to their function in other bacterial species, we report a positive role for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Methicillin-Resistant Staphylococcus aureus

Share to Microbial Sensitivity Tests

Share to Operon

Share to Vancomycin

Share to Vancomycin Resistance

Source

Open in PubMed Open full text

Identifiers

PMID: 27600558
DOI: 10.1038/srep30823
PMCID: PMC5013275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vancomycin susceptibility in methicillin-resistant Staphylococcus aureus is mediated by YycHI activation of the WalRK essential two-component regulatory system.PMID 27600558Read ↗

Mutation in the Two-Component System Regulator YycH Leads to Daptomycin Tolerance in Methicillin-Resistant Staphylococcus aureus upon Evolution with a Population Bottleneck.Semantic proximity Read ↗

SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureusSemantic proximity Read ↗

A mechanistic understanding of the effect of Staphylococcus aureus VraS histidine kinase single-point mutation on antibiotic resistanceSemantic proximity Read ↗

Role in cell permeability of an essential two-component system in Staphylococcus aureus.Semantic proximity Read ↗

The two-component regulator WalKR provides an essential link between cell wall homeostasis with DNA replication in <i>Staphylococcus aureus</i>Semantic proximity Read ↗

A novel mutation of walK confers vancomycin-intermediate resistance in methicillin-susceptible Staphylococcus aureus.Semantic proximity Read ↗

The two-component system WalKR provides an essential link between cell wall homeostasis and DNA replication in Staphylococcus aureusSemantic proximity Read ↗

The Staphylococcus aureus LytSR two-component regulatory system affects biofilm formation.Semantic proximity Read ↗

A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance.Semantic proximity Read ↗

YjbH contributes to Staphylococcus aureus skin pathology and immune response through Agr-mediated α-toxin regulationSemantic proximity Read ↗

walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus.Semantic proximity Read ↗

A defect in cell wall recycling confers antibiotic resistance and sensitivity in Staphylococcus aureusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.