Article
Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2017
Hargreaves Adam D, Zhou Long, Christensen Josef, Marlétaz Ferdinand, Liu Shiping, Li Fang, Jansen Peter Gildsig, Spiga Enrico, Hansen Matilde Thye, Pedersen Signe Vendelbo Horn, Biswas Shameek, Serikawa Kyle, Fox Brian A, Taylor William R, Mulley John Frederick, Zhang Guojie, Heller R Scott, Holland Peter W H
Abstract excerpt
The sand rat Psammomys obesus is a gerbil species native to deserts of North Africa and the Middle East, and is constrained in its ecology because high carbohydrate diets induce obesity and type II diabetes that, in extreme cases, can lead to pancreatic failure and death. We report the sequencing of the sand rat genome and discovery of an unusual, extensive, and mutationally biased GC-rich genomic domain. This...
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