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A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes

7 Nov 2022

Abstract excerpt

BACKGROUND: The Nile rat (Avicanthis niloticus) is an important animal model because of its robust diurnal rhythm, a cone-rich retina, and a propensity to develop diet-induced diabetes without chemical or genetic modifications. A closer similarity to humans in these aspects, compared to the widely used Mus musculus and Rattus norvegicus models, holds the promise of better translation of research findings to the...

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PMID: 36344967
DOI: 10.1186/s12915-022-01427-8

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