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Whole Genome Sequencing Indicates Heterogeneity of Hyperostotic Disorders in Dogs.

Genes - 4 Feb 2020

Letko Anna, Leuthard Fabienne, Jagannathan Vidhya, Corlazzoli Daniele, Matiasek Kaspar, Schweizer Daniela, Hytönen Marjo K, Lohi Hannes, Leeb Tosso, Drögemüller Cord

Abstract excerpt

Craniomandibular osteopathy (CMO) and calvarial hyperostotic syndrome (CHS) are proliferative, non-neoplastic disorders affecting the skull bones in young dogs. Different forms of these hyperostotic disorders have been described in many dog breeds. However, an incompletely dominant causative variant for CMO affecting splicing of SLC37A2 has been reported so far only in three Terrier breeds. The purpose of this...

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Identifiers

PMID: 32033218
DOI: 10.3390/genes11020163
PMCID: PMC7074049

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