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Article

Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults.

Alzheimer's research & therapy - 3 Jul 2017

Li Ge, Shofer Jane B, Petrie Eric C, Yu Chang-En, Wilkinson Charles W, Figlewicz Dianne P, Shutes-David Andrew, Zhang Jing, Montine Thomas J, Raskind Murray A, Quinn Joseph F, Galasko Douglas R, Peskind Elaine R

Abstract excerpt

BACKGROUND: This study sought to evaluate gender and APOE genotype-related differences in the concentrations of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) and cerebrovascular injury across the life span of cognitively normal adults. METHODS: CSF amyloid beta1-42 (Aβ42), phospho-tau-181 (p-tau181), and total tau were measured in 331 participants who were between the ages of 21 and 100. CSF...

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Identifiers

PMID: 28673336
DOI: 10.1186/s13195-017-0271-9
PMCID: PMC5496132

Genes

APOE
VCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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