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Article

Genetic association test based on principal component analysis.

Statistical applications in genetics and molecular biology - 26 Jul 2017

Chen Zhongxue, Han Shizhong, Wang Kai

Abstract excerpt

Many gene- and pathway-based association tests have been proposed in the literature. Among them, the SKAT is widely used, especially for rare variants association studies. In this paper, we investigate the connection between SKAT and a principal component analysis. This investigation leads to a procedure that encompasses SKAT as a special case. Through simulation studies and real data applications, we compare the...

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PMID: 28672760
DOI: 10.1515/sagmb-2016-0061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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