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Article

An approach to incorporate linkage disequilibrium structure into genomic association analysis.

Journal of genetics and genomics = Yi chuan xue bao - 1 Jun 2008

Zhang Fengyu, Wagener Diane

Abstract excerpt

In this study, we propose to use the principal component analysis (PCA) and regression model to incorporate linkage disequilibrium (LD) in genomic association data analysis. To accommodate LD in genomic data and reduce multiple testing, we suggest performing PCA and extracting the PCA score to capture the variation of genomic data, after which regression analysis is used to assess the association of the disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18571127
DOI: 10.1016/S1673-8527(08)60055-7
PMCID: PMC2746675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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