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Article

Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain.

The Journal of biological chemistry - 25 Jun 2010

Luong Phi, Kinch Lisa N, Brautigam Chad A, Grishin Nick V, Tomchick Diana R, Orth Kim

Abstract excerpt

The bacterial pathogen Vibrio parahemeolyticus manipulates host signaling pathways during infections by injecting type III effectors into the cytoplasm of the target cell. One of these effectors, VopS, blocks actin assembly by AMPylation of a conserved threonine residue in the switch 1 region of Rho GTPases. The modified GTPases are no longer able to interact with downstream effectors due to steric hindrance by...

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Identifiers

PMID: 20410310
DOI: 10.1074/jbc.M110.114884
PMCID: PMC2888428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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