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Article

Hypomorphic A20 expression confers susceptibility to psoriasis.

PloS one - 1 Jan 2017

Aki Anri, Nagasaki Miyuki, Malynn Barbara Ann, Ma Averil, Kagari Takashi

Abstract excerpt

Psoriasis is a common inflammatory skin disease that affects approximately 1% of the population worldwide. Tumor necrosis factor-alpha-induced protein 3 (TNFAIP3) gene polymorphisms have been strongly associated with psoriasis susceptibility. In this study, we investigate how TNFAIP3, also known as A20, may regulate psoriasis susceptibility. We found that haplo-insufficient A20+/- mice develop severe toll-like...

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Source

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Identifiers

PMID: 28658319
DOI: 10.1371/journal.pone.0180481
PMCID: PMC5489224

Genes

TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Hypomorphic A20 expression confers susceptibility to psoriasis.PMID 28658319Read ↗

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Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases.Semantic proximity Read ↗

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