Article
Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function.
Circulation. Heart failure - 1 Jan 2012
van Dijk Sabine J, Paalberends E Rosalie, Najafi Aref, Michels Michelle, Sadayappan Sakthivel, Carrier Lucie, Boontje Nicky M, Kuster Diederik W D, van Slegtenhorst Marjon, Dooijes Dennis, dos Remedios Cris, ten Cate Folkert J, Stienen Ger J M, van der Velden Jolanda
Abstract excerpt
BACKGROUND: Hypertrophic cardiomyopathy (HCM), typically characterized by asymmetrical left ventricular hypertrophy, frequently is caused by mutations in sarcomeric proteins. We studied if changes in sarcomeric properties in HCM depend on the underlying protein mutation. METHODS AND RESULTS: Comparisons were made between cardiac samples from patients carrying a MYBPC3 mutation (MYBPC3(mut); n=17), mutation...
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