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Article

Combined Proteomic-Molecular Epidemiology Approach to Identify Precision Targets in Brain Cancer.

ACS chemical neuroscience - 17 Jan 2018

Mostovenko Ekaterina, Liu Yanhong, Amirian E Susan, Tsavachidis Spiridon, Armstrong Georgina N, Bondy Melissa L, Nilsson Carol L

Abstract excerpt

Primary brain tumors are predominantly malignant gliomas. Grade IV astrocytomas (glioblastomas, GBM) are among the most deadly of all tumors; most patients will succumb to their disease within 2 years of diagnosis despite standard of care. The grim outlook for brain tumor patients indicates that novel precision therapeutic targets must be identified. Our hypothesis is that the cancer proteomes of glioma tumors...

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Identifiers

PMID: 28657708
DOI: 10.1021/acschemneuro.7b00165
PMCID: PMC5764832

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