Article

Identification of astrocytomas through serum protein fingerprint using MALDI-TOF MS and machine learning

2025-02-27

Abstract excerpt

Gliomas account for most brain malignancies, with astrocytomas being the most common subtype. Among these, glioblastoma (GBM) stands out as the most aggressive form, exhibiting a median survival time of just 15 months despite intensive therapy. Current diagnostic practices rely on magnetic resonance imaging (MRI) and histopathological analysis, which often necessitate invasive surgical sampling. This underscores t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9c39837-c8c9-507c-a6c6-4d8592268493
DOI: 10.1101/2025.02.21.639567

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of astrocytomas through serum protein fingerprint using MALDI-TOF MS and machine learningDOI 10.1101/2025.02.21.639567Read

Multi-pronged proteomic analysis to study the glioma pathobiology using cerebrospinal fluid samples.Semantic proximity Read

A large-scale targeted proteomics of serum and tissue shows the utility of classifying high grade and low grade meningioma tumorsSemantic proximity Read

Glioma Pathophysiology: Insights Emerging from ProteomicsSemantic proximity Read

Proteomic landscape of primary and metastatic brain tumors for heterogeneity discovery.Semantic proximity Read

Absolute quantification of 2-hydroxyglutarate on tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging for rapid and precise identification of isocitrate dehydrogenase mutations in human glioma.Semantic proximity Read

Proteomic landscape of primary and metastatic brain tumors for heterogeneity discoverySemantic proximity Read

Distinguishing IDH mutation status in gliomas using FTIR-ATR spectra of peripheral blood plasma indicating clear traces of protein amyloid aggregationSemantic proximity Read

Protocol for AI-powered classification of IDH-mutant astrocytoma using GUIDE.Semantic proximity Read

Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status.Semantic proximity Read

Integrated proteomic analysis of low-grade gliomas reveals contributions of 1p-19q co-deletion to oligodendroglioma.Semantic proximity Read

Proteomic landscape of primary and metastatic brain tumors for heterogeneity discoverySemantic proximity Read

Distinguishing IDH mutation status in gliomas using FTIR-ATR spectra of peripheral blood plasma indicating clear traces of protein amyloid aggregation.Semantic proximity Read