Article
Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2017
Miyazaki Taisuke, Yamasaki Miwako, Hashimoto Kouichi, Kohda Kazuhisa, Yuzaki Michisuke, Shimamoto Keiko, Tanaka Kohichi, Kano Masanobu, Watanabe Masahiko
Abstract excerpt
Astrocytes regulate synaptic transmission through controlling neurotransmitter concentrations around synapses. Little is known, however, about their roles in neural circuit development. Here we report that Bergmann glia (BG), specialized cerebellar astrocytes that thoroughly enwrap Purkinje cells (PCs), are essential for synaptic organization in PCs through the action of the l-glutamate/l-aspartate transporter...
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